Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.
نویسندگان
چکیده
Melanie J. Percy, Nauman N. Butt, Gerard M. Crotty, Mark W. Drummond, Claire Harrison, Gail L. Jones, Matthew Turner, Jonathan Wallis, and Mary Frances McMullin Department of Haematology, Belfast City Hospital, Belfast, Northern Ireland, UK; Department of Haematology, Arrowe Park Hospital, Wirral, England, UK; Regional Department of Haematology, Midland Regional Hospital at Tullamore, Tullamore, Ireland; Department of Haematology, University of Glasgow, Glasgow, Scotland, UK; Department of Haematology, St Thomas’ Hospital, London, England, UK; Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, England, UK; Department of Haematology, Queen’s University of Belfast, Belfast, Northern Ireland, UK
منابع مشابه
Detection of twelve nucleotides insertion in the BCR-ABL kinase domain in an imatinib-resistant but dasatinib-sensitive patient with bi-phenotypic acute leukemia.
in normal lymphocytes (Figure 2E). In samples from ALL patients, however, equivalent expression levels of PKM1/2 and PKM2 were present (Figure 2F). Analogous to the Q-PCR results, no significant difference in protein levels were observed between prednisolone-resistant and prednisolone–sensitive cases, suggesting that pyruvate kinase isoform M2 is not responsible for glucocorticoid resistance in...
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ورودعنوان ژورنال:
- Haematologica
دوره 94 9 شماره
صفحات -
تاریخ انتشار 2009